期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 119, 期 4, 页码 390-394出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.11188SC
关键词
polymethoxy flavonoid; inflammatory bone resorption; periodontal disease
Nobiletin, a polymethoxy flavonoid (PMF), inhibits systemic bone resorption and maintains bone mass in estrogen-deficient ovariectomized mice. This study examined the anti-inflammatory effects of PMFs, nobiletin, and tangeretin on lipopolysaccharide (LPS)-induced bone resorption. Nobiletin and tangeretin suppressed LPS-induced osteoclast formation and bone resorption and suppressed the receptor activator of NF kappa B ligand-induced osteoclastogenesis in RAW264.7 macrophages. Nobiletin clearly restored the alveolar bone mass in a mouse experimental model for periodontitis by inhibiting LPS-induced bone resorption. PMFs may therefore provide a new therapeutic approach for periodontal bone loss.
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