期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 115, 期 2, 页码 230-234出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10224SC
关键词
collagen; keratinocyte; pantothenic acid
资金
- Ministry of Education, Culture, Sports, Science, and Technology [19659011, 20054002]
- Smoking Research Foundation
- Japan Science Society
- Grants-in-Aid for Scientific Research [20054002, 19659011] Funding Source: KAKEN
It has been reported that pantothenic acid (vitamin B5) and panthenol, an alcohol derivative of pantothenic acid, have beneficial moisturizing effects on the skin. However, few studies have investigated the mechanism of action of pantothenic acid on skin tissues. We tried to clarify the role of pantothenic acid on skin function by using keratinocytes and fibroblasts. The depletion of pantothenic acid from the culture medium suppressed keratinocyte proliferation and promoted differentiation. Moreover, pantothenic acid depletion decreased the synthesis of keratinocyte growth factor and procollagen 4a2 in fibroblasts. These results suggest that pantothenic acid is essential for maintaining keratinocyte proliferation and differentiation.
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