期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 114, 期 3, 页码 269-275出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.10R11FM
关键词
Alzheimer's disease; bioinformatics; microRNA; neuropathology
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [S0801043]
- Ministry of Health, Labour, and Welfare of Japan [H22-Nanchi-Ippan-136]
MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. They play a key role in neuronal development, differentiation, and synaptic plasticity. However, at present, the pathological implications of deregulated miRNA expression in neurodegenerative diseases remain largely unknown. This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains.
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