期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 107, 期 4, 页码 465-470出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.SC0070374
关键词
simvastatin; acute pretreatment; ischemia-reperfusion (I/R) renal injury
资金
- Ministry of Science, Republic of Serbia [145001]
Acute pretreatment with a single i.v. bolus injection of simvastatin (1 mg/kg) significantly protects rat kidney injured by ischemia-reperfusion (I/R) (45 min + 6 h). We aimed to determine the optimal timing of such a pretreatment. The effects of both injections of simvastatin before ischemia and reperfusion were similar regarding total histological score. However, simvastatin injected 30 min before ischemia was 30% - 75% more effective in reduction of serum creatinine levels and interstitial edema score, while its injections 5 and 30 min before reperfusion were 25%-60% more effective in reduction of tubular necrosis score and fractional excretion of Na+. However, the observed differences do not seem to offer significant advantage in clinical settings.
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