期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 107, 期 2, 页码 221-225出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08002SC
关键词
pterin derivative; anticancer drug; photodynamic effect
To evaluate the feasibility of two kinds of pterin derivatives, 2-(NN-dimethylaminoinethyleneamirio)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.
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