期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 107, 期 11, 页码 2742-2747出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.xphs.2018.07.014
关键词
Caco-2 cells; ABC transporters; Madin-Darby canine kidney (MDCK) cells; in vitro models; drug interaction
Breast cancer resistance protein (BCRP) is a point of interest in drug-drug interaction safety testing. Therefore, a consensus probe that can be applied as victim in multiple experimental settings is of great benefit. Identification of candidates has been driven by the amount and quality of available clinical data, and as a result, drugs such as sulfasalazine and rosuvastatin have been suggested. In this article, the in vitro performance of 5 possible alternatives was evaluated: atorvastatin, chlorothiazide, dantrolene, topotecan, and teriflunomide, and benchmarked against sulfasalazine and rosuvastatin in reference in vitro assays for BCRP drug-drug interaction testing. Based on the results, teriflunomide is proposed as an alternate in vitro BCRP probe. (c) 2018 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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