期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 102, 期 1, 页码 185-194出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.23361
关键词
polymeric drug carrier; encapsulation; supercritical fluids; drying; alginate
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR) within PRIN
In this study, a novel preparation method for alginate-based aerogels charged with nonsteroidal anti-inflammatory drugs (NSAIDs) was developed using prilling in combination with supercritical fluid technique. Nanoporous carriers were prepared by laminar jet breakup of drug/alginate solutions or suspensions followed by cross-linking in ethanol or aqueous CaCl2 solutions, water replacement, and supercritical-CO2-assisted drying. A substantial drug loss was observed for highly soluble ketoprofen lysinate, whereas encapsulation efficiency was satisfying for slightly soluble ketoprofen. The tandem technique successfully produced almost spherical aerogels (sphericity coefficient 0.970.99) in narrow size distribution with reduced particle shrinkage and smooth surface (surface roughness 1.101.13); the internal porous texture of the parent hydrogels was preserved and appeared as a network of nanopores with diameters around 200?nm. Drug release profiles were monitored using a pH change method to evaluate the possible application of the aerogels as fast dissolving NSAIDs formulation. Aqueous cross-linking led to aerogels encapsulating ketoprofen in the amorphous form and with an enhanced burst effect in simulated gastric fluid (75% in 30?min), whereas ethanol cross-linking produced aerogels embedding drug in crystal clusters with slower dissolution rate. The system appears an interesting potential carrier for the fast delivery of slightly soluble drugs in the upper gastrointestinal tract. (c) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:185194, 2013
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据