期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 101, 期 4, 页码 1496-1507出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.23038
关键词
chemical stability; atomic force microscopy; excipients; drug interactions; solid state stability; degradation products; crystals; surface chemistry; microscopy; materials science; moisture sorption
资金
- Pfizer Institute for Pharmaceutical Material Science (Universiy of Cambridge, Cambridge CB2 3QZ, UK)
Atomic force microscopy (AFM) cantilevers were functionalized with particles of dicalcium phosphate dihydrate (DCP), and AFM, in forcedisplacement mode, was used to bring these probes into contact with aspirin (100) and (001) surfaces in order to investigate the effect of aspirin surface chemistry on the interaction between the two materials as a function of relative humidity (RH). The force of adhesion measurements showed a strong dependence on RH for the interactions between DCP and the aspirin (100) surface, with stronger interactions occurring at higher humudities. Relatively much weaker interactions were measured between DCP and the aspirin (001) surface under all RH conditions. Topographic imaging showed that contact between DCP and the aspirin (100) surface at high RH led to localised development of etch pits and, in some cases, growth normal to the surface. The methodology allows for the creation of a localised solidsolid interface between pharmaceutically relevant materials, providing a means of studying solid-state excipient-active ingredient decomposition reactions. (c) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:14961507, 2012
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