期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 100, 期 12, 页码 5293-5298出版社
WILEY-BLACKWELL
DOI: 10.1002/jps.22709
关键词
blood-plasma ratio; blood cell partitioning; protein binding; pharmacokinetics; distribution; thermodynamics; bioanalysis
A practical time-saving method of determination of equilibrium blood-plasma concentration ratio is described. The method is based on the analysis of compound plasma concentrations in regular blood sample and the blood sample diluted with blank plasma. Since only plasma concentrations are analyzed, the method can be conveniently applied in routine pharmacokinetic studies with minimal additional work for obtaining blood-plasma ratio. The method can also be easily used in in vitro experiment. The results obtained by suggested method are in good agreement with that obtained by common in vitro measurements of blood-plasma ratio. (C) 2011Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:5293-5298, 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据