期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 100, 期 5, 页码 1833-1846出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.22422
关键词
Naltrexone hydrochloride; diabetic keratopathy; niosomes; discomes; bilayer; calorimetry (DSC); controlled delivery; formulation; liposomes
资金
- Culture Affairs and Mission Department, Ministry of Higher Education, Cairo, Egypt
This study aimed at preparing and evaluating Span 60-based niosomes for ocular delivery of naltrexone hydrochloride (NTX). Selected charged lipids [dicetyl phosphate (DCP) and stearyl amine (STA)] and surfactants [poly-24-oxyethylene cholesteryl ether (C24) and sodium cholate (CH)] were investigated as bilayer membrane additives and prepared using four different methods. A 5-fold increase in NTX entrapment efficiency (EE%) was achieved with 2%-5% mol/mol additives. Differential scanning calorimetry thermograms revealed that the additives completely abolished gel/liquid transition suggesting that the bilayer membranes could accommodate the additives. The volume diameters D (4, 3) of the prepared niosomes were significantly [p < 0.05, analysis of variance (ANOVA)] dependent on the additive used. D (4,3) values of F-C24 and F-CH were 22.41 +/- 1.40 and 5.37 +/- 1.40 mu m, respectively. F-S60, F-DCP, and F-CH shapes were typical spherical, whereas F-C24 was oval giant niosomes (discomes ). In vitro drug release parameters showed that the prepared niosomes significantly (p < 0.01, ANOVA) controlled NTX release rate and extent. Ex vivo transcorneal permeation studies conducted using excised cow corneas showed that niosomes were capable of controlling NTX permeation and enhance its corneal permeability. The prepared niosomal formulations were found practically nonirritant when applied onto the surface of a 10-day-old hen's chorioallantoic membrane. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:1833-1846, 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据