期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 100, 期 8, 页码 3411-3420出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.22535
关键词
amorphous; compression; dissolution; itraconazole; SBA-15; COK-12; mesoporous silica; physical characterization; solid dosage form
资金
- Flemish Government
- Flemish Fund for Scientific Research (FWO)
Ordered mesoporous silica (OMS) materials are considered a promising drug delivery system for the dissolution enhancement of poorly soluble compounds. The purpose of the present work was to determine structural and behavioral changes of compressed OMS material necessary for the development of an immediate-release oral-dosage formulation. Two types of OMS materials (SBA-15 and COK-12) were subjected to pressures both in and beyond the tabletting region and characterized by nitrogen physisorption, scanning and transmission electron microscopy, small-angle X-ray scattering, and differential scanning calorimetry. Itraconazole was used as the poorly soluble model drug and the release process with respect to pressure was determined in vitro. The resulting decreased drug release due to increased pressure was recovered by incorporating a plastically deforming material such as microcrystalline cellulose in combination with croscarmellose sodium. These findings further elucidate the understanding of their structural behavior for the advancement as a drug delivery carrier. (C) 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:3411-3420, 2011
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