期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 99, 期 3, 页码 1107-1122出版社
WILEY
DOI: 10.1002/jps.21916
关键词
protein binding; pharmacokinetics; pharmacodynamics; clearance; drug effects
The significance of plasma protein binding on drug efficacy and, subsequently, the clinical relevance of changes in protein binding has been controversially discussed for decades. The uncertainty concerning the impact of plasma protein binding on a drug's pharmacological activity is, in part, related to the approach used when investigating and interpreting protein binding effects in vitro and in vivo. Frequently, a generalized one-size-fits-all approach, such as protein binding does matter/does not matter, may not be applicable. An appropriate analysis requires careful consideration of both pharmacokinetic and pharmacodynamic processes, as they both contribute to the safety and efficacy of drugs. Therefore, the aim of this article is to provide a concise review of the theoretical concepts of protein binding, and to discuss relevant examples where applicable. (C) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:1107-1122, 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据