期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 99, 期 1, 页码 475-485出版社
WILEY-BLACKWELL
DOI: 10.1002/jps.21798
关键词
physiologically based pharmacokinetic model; perfusion limited model; well-stirred model; perfusion volume; tissue-plasma partition coefficient; blood-plasma concentration ratio; steady state volume of distribution; clearance
A consistent account of the assumptions of the well-stirred perfusion limited model leads to the equation for the organ tissue that does not coincide with that often presented in books and papers. The difference in pharmacokinetic profiles calculated by the valid and the commonly used equations could be quite significant, particularly due to contribution of the organs with relatively large perfusion volume, and especially for drugs with small tissue-plasma partition coefficient and high blood-plasma concentration ratio. Application of the valid equation may result in much faster initial drop of drug plasma concentration time curve and significantly longer terminal half-life, especially for low extraction ratio drugs. An equation for the steady state volume of distribution consistent with the well-stirred model described by the valid equation is provided. (C) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:475-485, 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据