期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 98, 期 12, 页码 4808-4817出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.21786
关键词
drying; nanoparticles; nanotechnology; freeze drying/lyophilization; freeze-drying; milling; particle size; suspensions
资金
- Chung-Ang University
Drug nanoparticles are often prepared in a liquid medium, and a drying method such as freeze drying is used to convert them to an oral solid dosage form. When the dried form is reconstituted in an aqueous system, it may be redispersed to achieve its original particle size. The redispersibility of dried nanoparticles depends on the parameters of the freeze drying process. In this study, an apparatus with a freezing rate gradient was used to systematically investigate the effect of cryoprotectants on the redispersibility of nanoparticles as a function of freezing rate. Sucrose, lactose, mannitol, and polyethylene glycol were used as cryoprotectants for a naproxen nano-suspension. A fast freezing rate and a high cryoprotectant concentration were generally favored. However, under certain conditions, a slower freezing rate resulted in better redispersibility. This is probably because slow freezing can produce a more cryo-concentrated liquid phase, and the concentrated cryoprotectant in the liquid phase can more effectively protect the nanoparticles. Am irreversible aggregation map was constructed as a function of the freezing rate and the cryoprotectant concentration, and shows both the favorable and unfavorable effects of cryoprotectants. (C) 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:4808-4817, 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据