期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 97, 期 4, 页码 1564-1577出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.21133
关键词
fluidized bed spray granulation; mass transfer; bed humidity; evaporation
humidity is a critical parameter that needs to be controlled in a fluidized bed granulation to ensure reliability. To predict and control the bed humidity during the fluidized bed granulation process, a simple model based on the mass conservation of moisture was developed. The moisture mass balance model quantitatively simulates the effects of spray rate, binder solution concentration, airflow rate, inlet air temperature, and dew point on the bed humidity. The model was validated by a series of granulations performed in different scale granulators including Glatt GPCG-1, GPCG-15, and GPCG-60. Good agreement was observed between the theoretical prediction and the measured loss on drying (LOD). The model developed in the current work enables us to choose the appropriate parameters for the fluidized bed granulation and can be used as a valuable tool in process scaling-up. (C) 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:1564-1577, 2008.
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