期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 92, 期 -, 页码 1-5出版社
ELSEVIER
DOI: 10.1016/j.jpba.2013.12.043
关键词
Dehalogenation impurities; Method development; Perfluorophenyl; UHPLC; HRMS
资金
- MRL Postdoctoral Research Fellows Program
- MRL New Technologies Review & Licensing Committee (NT-RLC)
The presence of dehalogenated impurities is often observed in halogen-containing pharmaceuticals, and can present a difficult analytical challenge, as the chromatographic behavior of the halogenated drug and the hydrogen-containing analog can be quite similar. In this study we describe the chromatographic separation and unambiguous identification of dehalogenation impurities or associated isomers in organohalogenated pharmaceuticals using UHPLC with a pentafluorophenyl column coupled with diode-array and high resolution electrospray ionization mass spectrometry detection (UHPLC-DAD-HRESIMS). (C) 2014 Elsevier B.V. All rights reserved.
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