期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 87, 期 -, 页码 98-104出版社
ELSEVIER
DOI: 10.1016/j.jpba.2013.05.014
关键词
Photodynamic therapy; Reactive oxygen species; Photosensitizer; Phthalocyanine
资金
- National Science Foundation of China [81201709, 81273548, 21101028]
- China Postdoctoral Science Foundation [2012M511441]
- Science and Technology Foundation of Fujian Province of China [2011J0104]
- Science Foundation of Education Department of Fujian Province of China [JK2010003]
Phthalocyanine (Pc) and its related derivatives are a class of functional materials that are easily activated by the light at a special wavelength. As such photosensitizer, Pc has been applied to photodynamic therapy (PDT), in addition to its broad applications in many fields, for both malignant and benign diseases. One of our long-term research focuses is to develop Pc for cancer therapy. Herein we briefly review mechanisms of action of Pc used for photodynamic therapy, its pharmaceutical development and molecular modification to enhance its drugability and improve its intracellular localization. We also describe the current status of the Pc derivatives under clinical investigation, and analyze the methods used for quantitative analysis of those Pc derivatives. (C) 2013 Elsevier B.V. All rights reserved.
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