期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 101, 期 -, 页码 141-150出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2014.05.021
关键词
Cell membrane chromatography; Traditional Chinese medicines; Drug-receptor interactions; Active components; Quality control
资金
- National Natural Science Foundation of China [81227802, 81230079]
- National Twelfth Five-Year Plan for Science & Technology Support of China [2012BAI29B06]
Traditional Chinese medicines (TCMs) have been used for preventative care for thousands of years. The active components are the basis for the pharmacodynamics of TCMs, and they can be an important source of lead compounds. As a bioaffinity chromatography technique, cell membrane chromatography (CMC) has been developed for almost 20 years since 1996. It has been proven to be a useful method for studying drug-receptor interactions and screening active components from medicinal herbs. In our review in 2007 (Drug Discov. Ther., 1 (2007) 104-107), the preparation, identification, evaluation, and preliminary applications of CMC stationary phases were presented. In this article, we briefly review some of the latest progress and applications about CMC including instrument development, research on drug-receptor interactions, screening active components from TCMs, and quality control of TCMs. (C) 2014 Elsevier B.V. All rights reserved.
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