期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 93, 期 -, 页码 17-26出版社
ELSEVIER
DOI: 10.1016/j.jpba.2013.09.025
关键词
NMR spectroscopy; Metabolomics; Blood; Urine; Disease
资金
- European Regional Development Fund-FEDER through the Competitive Factors Thematic Operational Programme-COMPETE
- Foundation for Science and Technology-FCT, Portugal [PEst-C/CTM/LA0011/2013]
- FCT [SFRH/BD/73343/2010]
- FCT funds
- Fundação para a Ciência e a Tecnologia [SFRH/BD/73343/2010] Funding Source: FCT
This paper reviews the main applications of NMR metabolomics of blood and urine in disease research, over the last 5 years. The broad range of disease types addressed attests the increasing interest within the academic and medical communities to explore the recognised potential of metabolomics to (1) provide insight into underlying disease pathogenesis and (2) unveil new metabolic markers for disease diagnosis and follow up. Importantly, most recent studies reveal an increasing awareness of possible limitations and pitfalls of the metabolomics approach, together with efforts for improved study design and statistical validation, which are crucial requisites for the sound development of NMR metabolomics and its progress into the clinical setting. (C) 2013 Elsevier B.V. All rights reserved.
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