期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 87, 期 -, 页码 313-325出版社
ELSEVIER
DOI: 10.1016/j.jpba.2013.09.003
关键词
Thermodynamics; Ionotropic receptors; G-protein coupled receptors; Transporters; Drug-target interactions
Isothermal titration calorimetry is a versatile method to characterize energetics of intermolecular reactions and in particular interactions between drug molecules and their macromolecular targets. The assay is widely used in medicinal chemistry to quantification and characterization of molecular mechanisms of these interactions. The article reviews applications of the method to study ligand interactions with various classes of embedded membrane proteins. These proteins constitute very important fraction of macromolecular targets for medicinal compounds used in current therapies and recently emerged for detailed structural, functional and biochemical characterization of their interactions with drug molecules. (C) 2013 Elsevier B.V. All rights reserved.
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