期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 69, 期 -, 页码 64-76出版社
ELSEVIER
DOI: 10.1016/j.jpba.2012.01.032
关键词
Monolithic supports; Affinity chromatography; IMERs; Protein immobilization; Enzyme activity
This mini-review reports on some recent advances in the field of immobilized protein employing both silica and polymer-based monoliths as supports, and their application in affinity chromatography and immobilized enzyme reactors (IMERs) developments. The major emphasis is put on some interesting challenges and opportunities related to the development of new monolithic affinity supports based on biofriendly sol-gel inorganic monoliths with entrapped proteins and on organic monolithic supports with improved hydrophilicity for IMERs development in proteomic studies. The ease of preparation of monoliths and the multitude of functionalization techniques, make monoliths interesting for an increasing number of biochemical and medical applications. (C) 2012 Elsevier B.V. All rights reserved.
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