期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 56, 期 4, 页码 678-683出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2011.07.005
关键词
Indomethacin; Photodecarboxylation; Photo-oxidation; Arylalkanoic acids; Mesolytic cleavage
Photochemical behaviour of indomethacin in aqueous media at 254 nm, 310 nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur. (C) 2011 Elsevier B.V. All rights reserved.
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