4.6 Article

Identification of novel sildenafil-analogues in an adulterated herbal food supplement

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ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2011.07.012

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Piperazinonafil; Adulterant; Dietary supplement; PDE-5 inhibitor; NMR

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A new herbal product advertised as potency pill was sent for analysis by the local authority. The product was tested for the presence of potential derivatives of PDE-5 inhibitors, such as sildenafil, vardenafil, and tadalafil. Sildenafil analogues were identified, in which the piperazine ring and the sulfonyl group were replaced by a piperazinone and a hydroxyethyl structure, respectively. The chemical structures were established by LC-MS in ESI negative mode, UV and NMR spectroscopy (including DEPT, HSQC, HMBC, H,H-COSY, H,H-TOCSY and H,H-NOESY experiments). This is the first report of piperazinonafil and isopiperazinonafil as adulterant in an herbal food supplement. (C) 2011 Elsevier B.V. All rights reserved.

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