期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 47, 期 4-5, 页码 746-749出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2008.03.003
关键词
paracetamol containing products; 4-aminophenol impurity; capillary electrophoresis; micellar electrokinetic chromatography (MEKC); sodium dodecyl sulphate (SDS)
A micellar electrokinetic chromatographic (MEKC) method was developed for the quality control of paracetamol containing pharmaceutical preparations. The influence of several factors (surfactant concentration, buffer concentration, pH and applied voltage) was studied during development and optimisation of the method. Phosphate buffer (pH 9.0) containing sodium dodecyl sulphate (75 mM) was found as the ideal running buffer for the separation; the applied voltage was 25 W and the analysis time was 10 min. The limit of quantitation for 4-aminophenol was 6 mu g ml(-1); the linearity of the method was studied in the concentration ranges 20-260 mu g ml(-1) for paracetamol and 20-150 mu g ml(-1) for 4-aminophenol. The method was successfully applied for the quality control of paracetamol containing products. (C) 2008 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据