4.6 Article

Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement

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出版社

ELSEVIER
DOI: 10.1016/j.jpba.2008.08.019

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Health supplement; PDE-5 inhibitor; Adulterant; Liquid chromatography (LC); Mass spectrometry (MS); Nuclear magnetic resonance (NMR)

资金

  1. Academic Research Fund

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A PDE-5 inhibitor was detected and isolated from a health supplement claimed to be a preparation of fresh oyster extracts and be able to promote and support healthy sexual function and endurance, etc. The structure of this PDE-5 inhibitor was elucidated using LC-UV, LC-TOF-MS, MS-MS, IR spectroscopy, and 2D NMR. It was characterized as 8-(2-(4-(hydroxymethyl)piperidin-1-yl)benzylamino)-3-ethyl-1-Himidazo[4,5-g]quinazoline-2(3H)-thione, a compound reported to be a PDE-5 inhibitor. (C) 2008 Elsevier B.V. All rights reserved.

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