期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 46, 期 4, 页码 814-817出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2007.12.007
关键词
dietary supplements; sildenafil analogue; thio-homosildenafil; liquid chromatography-mass spectrometry (LC-MS); nuclear magnetic resonance (NMR)
A new analogue of sildenafil was detected in a herbal aphrodisiac. The structure of the compound was established using LC-MS, UV and IR spectroscopy, MS-MS, and NMR. The compound, named thio-homosildenafil is a synthetic N-ethylpiperazine analogue of sildenafil in which also the C=O moiety has been converted into a C=S group. This is the first time a sildenafil analogue modified at the chromophore was identified as an adulterant of a herbal aphrodisiac. Preliminary pharmacological analysis confirmed the erectogenic potency of thio-homosildenafil. (C) 2007 Elsevier B.V. All rights reserved.
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