期刊
JOURNAL OF PERIODONTOLOGY
卷 80, 期 9, 页码 1433-1439出版社
AMER ACAD PERIODONTOLOGY
DOI: 10.1902/jop.2009.090077
关键词
Alveolar bone; calcium; chronic periodontitis; vitamin D
资金
- National Institute of Dental and Craniofacial Research (NIDCR) [R21 DE016918-01A2]
- National Center for Research Resources (NCRR) [CILI RR024992]
- National Institutes of Health (NIH), Bethesda, Maryland
- NIH Roadmap for Medical Research
Background: A low dietary intake of vitamin D and calcium hastens bone loss and osteoporosis. Because vitamin D metabolites may also alter the inflammatory response and have antimicrobial effects, we studied whether the use of vitamin D and calcium supplements affects periodontal disease status. Methods: A cohort of 51 subjects receiving periodontal maintenance therapy was recruited from two dental clinics; 23 were taking vitamin D (>= 400 IU/day) and calcium (>= 1,000 mg/day) supplementation, and 28 were not taking such supplementation. All subjects had at least two interproximal sites with >= 3 mm clinical attachment loss. Daily calcium and vitamin D intake (from food and supplements) were estimated by nutritional analysis. The following clinical parameters of periodontal disease were recorded for the mandibular posterior teeth: gingival index, probing depth, cemento-enamel junction-gingival margin distance (attachment loss), bleeding on probing, and furcation involvement. Posterior photostimulable-phosphor bitewing radiographs were taken to determine cemento-enamel junction-alveolar crest distances (alveolar crest height loss). Data were analyzed with a repeated-measures multivariate analysis of variance. Results: Compared to subjects who did not take vitamin D and calcium supplementation, supplement takers had shallower probing depths, fewer bleeding sites, lower gingival index values, fewer furcation involvements, less attachment loss, and less alveolar crest height loss. The repeated-measures analysis indicated that collectively these differences were borderline significant (P = 0.08). Conclusions: In these subjects receiving periodontal maintenance therapy, there was a trend for better periodontal health with vitamin D and calcium supplementation. More expanded longitudinal studies are required to determine the potential of this relationship. J Periodontol 2009;80:1433-1439.
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