期刊
JOURNAL OF PERIODONTOLOGY
卷 79, 期 8, 页码 1592-1600出版社
WILEY
DOI: 10.1902/jop.2008.080174
关键词
Bisphosphonates; bone resorption; matrix metalloproteinases; periodontitis
资金
- NCRR NIH HHS [UL1 RR024986-02, UL1 RR 024986, UL1 RR024986] Funding Source: Medline
- NIDCR NIH HHS [U01 DE014961, U01 DE014961-04, U01 DE 14961] Funding Source: Medline
Periodontal diseases are initiated by Gram-negative tooth-associated microbial biofilms that elicit a host response, with resultant osseous and soft tissue destruction. In response to endotoxins derived from periodontal pathogens, several osteoclast-related mediators target the destruction of alveolar bone and supporting connective tissues. Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins, and other osteoclast-derived enzymes. This article focuses on the downstream factors of the osteoclast responsible for the degradation of bone and soft tissues around teeth and oral implants. Furthermore, therapeutic approaches that target MMP-2, -8, and -9 inhibition, such as MMP inhibitors, chemically modified tetracyclines, and sub-antimicrobial formulations of tetracycline analogues, are discussed. The use of rapid, chair-side tests of MMP activity, in particular for MMP-8 and bone collagen fragments, show strong potential as non-invasive measures of tissue health or disease. In addition, studies using other agents for the preservation of bone mass, such as bisphosphonates that inhibit osteoclast recruitment, are highlighted. The application of these bone-preservation strategies to periodontal management and treatment are discussed in the context of high-risk patients susceptible to disease reactivation or disease complications. J Periodontol 2008;79:1592-1600.
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