期刊
JOURNAL OF PERIODONTAL RESEARCH
卷 48, 期 6, 页码 706-712出版社
WILEY
DOI: 10.1111/jre.12058
关键词
antibiotics; chronic periodontitis; diabetes; non-surgical periodontal therapy
资金
- Colgate-Palmolive [020-2009]
- Universidad de Antioquia
Background and ObjectivePeriodontitis may alter the systemic condition in patients with diabetes and hence interfere with glycemic control. The objective of this study was to determine the quantifiable changes in glycated hemoglobin (HbA1C) after periodontal non-surgical therapy plus azithromycin in a mixed population of patients with poorly controlled diabetes. Materials and MethodsOne hundred and five patients were randomized to receive non-surgical therapy plus azythromycin (AZ-Sca =33), non-surgical therapy plus placebo (PB-Sca=37) and supragingival prophylaxis plus azithromycin (AZ-Pro=35). Glycated hemoglobin, glycemia and periodontal parameters were measured at baseline, 3, 6 and 9mo after treatment. ResultsPeriodontal parameters were improved in the AZ-Sca and PB-Sca groups as compared to the AZ-Pro group. A greater reduction in probing depth was observed in the AZ-Sca as compared to the PB-Sca group. Improvement in clinical attachment level was similar between AZ-Sca and PB-Sca groups. A reduction from 8.0% to 7.2% (0.8%; p<0.05) in HbA1C was observed in the AZ-Sca at 9mo as compared to the PB-Sca group in which the reduction was from 7.9% to 7.6% (0.3%). There was no decrease in HbA1C in the AZ-Pro group over time. Mean glycemia values decreased from 195mg/dL to 159.2mg/dL (35.8mg/dL; p<0.05) in the AZ-Sca group whereas a decrease from 194mg/dL to 174.8mg/dL (19.2mg/dL) in the PB-Sca group at 9mo was observed. There were no differences between the AZ-Sca and PB-Sca groups for glycemic parameters. No improvement in glycemic values in the AZ-Pro group was observed. ConclusionsA modest improvement in glycemic control was detected with a trend towards the use of non-surgical therapy plus AZ as compared to the placebo.
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