期刊
JOURNAL OF PERIODONTAL RESEARCH
卷 48, 期 3, 页码 367-372出版社
WILEY
DOI: 10.1111/jre.12016
关键词
cytomegalovirus; inflammation; periodontal disease
资金
- National Institute of Dental & Craniofacial Research [R21 DE019950]
- National Institute on Aging [P30AG017265, T32AG0037]
Levine ME, Kim JK, Crimmins EM. The role of physiological markers of health in the association between demographic factors and periodontal disease. J Periodont Res 2013; 48: 367-372. (C) 2012 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background and Objective Age is highly related to oral health status. The higher prevalence of oral disease within subgroups of the population may reflect a tendency towards early aging and dysregulation of multiple physiological systems. This study examines whether the association between periodontal disease and demographic factors is mediated by physiological measures of health. Material and Methods Logistic regression was used to examine whether biomarkers and demographic factors, such as socio-economic status (SES) and race/ethnicity, were associated with periodontal disease, and then whether the strength of these relationships could be attributed to associations between demographic variables and physiological measures of systemic health. Results Periodontal disease was associated with measures of SES and race/ethnicity. Furthermore, 1-unit increases in cytomegalovirus (CMV), optical density, C-reactive protein (CRP) and glycated hemoglobin (HbA1c) were associated with a 25% [odds ratio (OR)=1.25; 95% confidence interval (CI): 1.141.36], 13% (OR = 1.13; 95% CI = 1.031.24) and 19% (OR = 1.19; 95% CI = 1.121.27) increased likelihood of periodontal disease, respectively. However, when biomarkers and socio-demographic variables were both included in the model, their associations with periodontal disease were significantly reduced or eliminated. Conclusions The risk of periodontal disease is higher among black and/or low-income individuals; however, these associations appear to be partly due to the greater probability of elevated levels of CRP, CMV or HbA1c among these groups.
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