期刊
JOURNAL OF PERINATOLOGY
卷 34, 期 6, 页码 435-440出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2014.41
关键词
-
资金
- Kaiser Permanente Direct Community Benefit Funds
OBJECTIVE: To examine whether inflammatory bowel disease (IBD) is associated with ischemic/inflammatory conditions during pregnancy. STUDY DESIGN: A retrospective cohort study using the 2000 to 2012 Kaiser Permanente Southern California maternally-linked medical records (n=395 781). The two major subtypes of IBD, ulcerative colitis and Crohn's diseases were studied. Adjusted odds ratios (ORs) were used to quantify the associations. RESULT: A pregnancy complicated by IBD was associated with increased incidence of small-for-gestational age birth (OR= 1.46, 95% confidence interval (CI) =1.14 to 1.88), spontaneous preterm birth (OR =1.32, 95% CI = 1.00 to 1.76) and preterm premature rupture of membranes (OR = 1.95, 95% CI = 1.26 to 3.02). Further stratifying by IBD subtypes, only ulcerative colitis was significantly associated with increased incidence of ischemic placental disease, spontaneous preterm birth and preterm premature rupture of membranes. CONCLUSION: The findings underscore the potential impact of maternal IBD on adverse perinatal outcomes. Clinicians should be aware that the association between IBD and adverse perinatal outcome varies by IBD subtypes.
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