期刊
JOURNAL OF PERINATOLOGY
卷 32, 期 11, 页码 844-850出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2012.12
关键词
endocrine-disrupting chemicals; ethnicity; pregnancy; race
资金
- March of Dimes Foundation [6-Fy06-311]
- Department of Obstetrics and Gynecology Research Development Fund, Medical University of South Carolina
Objective: To determine if racial disparities exist in maternal and fetal cord serum concentrations of bisphenol A (BPA). Study Design: A nested cross-sectional study was performed from a cohort of 600 term nulliparas. In 27 patients (8 Caucasian, 8 African-American and 11 Hispanic), term pre-labor maternal serum and corresponding fetal-cord serum were analyzed for BPA. Result: African-Americans had the highest maternal serum concentrations, 10-fold higher than Caucasians (30.13 vs 3.14 ng ml(-1) P = 0.038). Hispanics had intermediate concentrations with a trend towards higher concentrations compared with Caucasians (24.46 vs 3.14 ng ml(-1); P = 0.051). Overall concentrations were 10-fold higher in maternal samples than fetal samples (14.1 vs 1.3 ng ml(-1); P = 0.001). Hispanics had higher fetal concentrations than non-Hispanics (2.05 vs 0.35 ng ml(-1); P = 0.025). Conclusion: We found significant racial/ethnic differences in maternal/fetal BPA concentrations. Further study is needed to determine if these differences reflect disparities in exposure, metabolism or placental transfer. Journal of Perinatology (201 2) 3 2, 844-850; doi:10.1038/jp.2012.12; published online 8 March 2012
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