期刊
JOURNAL OF PERINATOLOGY
卷 29, 期 2, 页码 79-88出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jp.2008.132
关键词
immunomodulation; adjuvant; neonatal; sepsis; Toll-like receptor; innate immunity
资金
- NIGMS NIH HHS [R01 GM040586, R01 GM097531] Funding Source: Medline
Prevention of neonatal infection-related mortality represents a significant global challenge particularly in the vulnerable premature population. The increased risk of death from sepsis is likely due to the specific immune deficits found in the neonate as compared to the adult. Stimulation of the neonatal immune system to prevent and/or treat infection has been attempted in the past largely without success. In this review, we identify some of the known deficits in the neonatal immune system and their clinical impact, summarize previous attempts at immunomodulation and the outcomes of these interventions, and discuss the potential of novel immunomodulatory therapies to improve neonatal sepsis outcome. Journal of Perinatology (2009) 29, 79-88; doi:10.1038/jp.2008.132; published online 4 September 2008
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