期刊
JOURNAL OF PERINATAL MEDICINE
卷 42, 期 2, 页码 225-231出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/jpm-2013-0147
关键词
Growth restriction; newborn; respiratory morbidity; preeclampsia; preterm
资金
- Swedish Medical Research Council [0037]
- Lund University Hospital Funds
- Uppsala University
Objective: Twin studies offer opportunities to investigate mechanisms underlying sex-associated differences in perinatal outcomes. The objective of the study was to investigate sex-related differences in perinatal complications. Study design: A cohort of 16,045 twin pregnancies 32,090 twins - was explored for obstetric complications, perinatal and infant mortality, and neonatal morbidities. Results: Twin pregnancies with a female fetus had an increased risk for preeclampsia, but otherwise there were no pregnancy complications associated with fetal sex. After birth, female-female twins had lower early neonatal and infant mortality, and lower risk for respiratory morbidities than male-male twins at all gestational ages. In unlike-sexed twin pairs, very preterm males had higher respiratory morbidity than females and, females were at higher risk for being growth restricted. Conclusion: Male-male twins have higher respiratory morbidity and neonatal mortality than female-female twins. In unliked-sexed twin pairs, the males seem to be protected by having a female co-twin.
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