期刊
JOURNAL OF PEPTIDE SCIENCE
卷 20, 期 4, 页码 235-239出版社
WILEY-BLACKWELL
DOI: 10.1002/psc.2624
关键词
protein mimic; discontinuous epitope; cyclic peptide; sequential cycloaddition; scaffold; orthogonal functionalization
资金
- Chemical Sciences of The Netherlands Organization for Scientific Research (NWO)
Synthetic mimics of discontinuous epitopes may have a wide range of potential applications, including synthetic vaccines and inhibition of protein-protein interactions. However, synthetic access to these relatively complex peptide molecular constructs is limited. This paper describes a versatile convergent strategy for the construction of protein mimics presenting three different cyclic peptides. Using an orthogonal alkyne protection strategy, peptide loops were introduced successively onto a triazacyclophane scaffold via Cu(I)-catalyzed azide alkyne cycloaddition. This method provides rapid access to protein mimics requiring different peptide segments for their interaction and activity. Copyright (C) 2014 European Peptide Society and John Wiley & Sons, Ltd.
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