期刊
JOURNAL OF PEPTIDE SCIENCE
卷 20, 期 9, 页码 675-679出版社
WILEY-BLACKWELL
DOI: 10.1002/psc.2664
关键词
nanoparticle; peptide; magnetic matrix; embedded nanoparticle; solid phase peptide synthesis
资金
- Israel Science Foundation [830/11]
- Israeli Ministry of Sciences
- Marcus Centre for Medicinal Chemistry of Bar Ilan University
- BIU
- Israel Council for Higher Education
We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides. Copyright (c) 2014 European Peptide Society and John Wiley & Sons, Ltd.
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