期刊
JOURNAL OF PEDIATRICS
卷 164, 期 4, 页码 795-U174出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2013.12.004
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资金
- National Science and Technology Pillar Program during the Eleven Five-Year Plan Period [2008BAI58B05]
- Program for New Century Excellent Talents in University of Ministry of Education of China [NCET-10-0148]
- National Institute for Nutrition and Food Safety
- China Centers for Disease Control and Prevention
Objective To assess the effect of aweight-loss program on improving iron status in overweight and obese schoolaged children. Study design The data were analyzed in overweight and obese children (7-11 years of age; 114 girls and 212 boys) with body mass index-for-age z-scores (BAZ) >1 from a weight-loss program. Schools were randomly divided into 2 groups: intervention and control. Children in the intervention group underwent a 1-year, nutritionbased comprehensive intervention weight-loss program. Anthropometric, dietary intake, and physical activity data were collected at baseline and follow-up (1 year). Iron status and inflammatory markers were assessed within a month. Results In the intervention group, BAZ decreased more than that in the control group (-0.4 +/- 0.7 vs -0.1 +/- 0.6, P < .0001); and iron profiles and inflammation status were improved at follow-up. In multivariable linear regression models, a greater decrease of BAZ and inflammation factors predicted a better improvement of iron status. After adjustment of Delta BAZ, Delta C-reactive protein was significantly associated with Delta serum ferritin (beta: 1.89; 95% CI, 0.70-3.09; P = .002) and Delta soluble transferrin receptor (beta: 0.88; 95% CI, 0.16-0.59; P = .017); Delta interleukin-6 was significantly associated with Delta serum ferritin (beta: 1.22; 95% CI, 0.64-1.79; P < .0001). Conclusions Iron status and inflammation were improved by weight reduction. The improvement in inflammatory markers during weight reduction was independently associated with improvements of iron status.
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