期刊
JOURNAL OF PEDIATRICS
卷 163, 期 2, 页码 549-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2013.02.002
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资金
- Bill and Melinda Gates Foundation
- The Wellcome Trust (United Kingdom)
- Institute of Nutrition of Central America
- Panama Nutrition Trial Cohort (Guatemala)
- US National Institutes of Health
- US National Science Foundation
- Pelotas Birth Cohort (Brazil) Wellcome Trust
- New Delhi Birth Cohort Study (India)
- Indian Council of Medical Research
- US National Center for Health Statistics
- Medical Research Council (United Kingdom)
- British Heart Foundation
- Birth to Twenty Cohort (South Africa)
- Wellcome Trust
- Human Sciences Research Council
- South African Medical Research Council
- South-African Netherlands Program on Alternative Development
- Anglo-American Chairman's Fund
- University of the Witwatersrand
- Cebu Longitudinal Health, and Nutrition Survey (the Philippines) US National Institutes of Health
- Medical Research Council [MC_UU_12011/3, MC_UP_A620_1016, G1001333, G0400519] Funding Source: researchfish
- MRC [G0400519, G1001333, MC_UU_12011/3, MC_UP_A620_1016] Funding Source: UKRI
Objective To examine associations between maternal height and child growth during 4 developmental periods: intrauterine, birth to age 2 years, age 2 years to mid-childhood (MC), and MC to adulthood. Study design Pooled analysis of maternal height and offspring growth using 7630 mother-child pairs from 5 birth cohorts (Brazil, Guatemala, India, the Philippines, and South Africa). We used conditional height measures that control for collinearity in height across periods. We estimated associations between maternal height and offspring growth using multivariate regression models adjusted for household income, child sex, birth order, and study site. Results Maternal height was associated with birth weight and with both height and conditional height at each age examined. The strongest associations with conditional heights were for adulthood and 2 years of age. A 1-cm increase in maternal height predicted a 0.024 (95% CI: 0.021-0.028) SD increase in offspring birth weight, a 0.037 (95% CI: 0.033-0.040) SD increase in conditional height at 2 years, a 0.025 (95% CI: 0.021-0.029 SD increase in conditional height in MC, and a 0.044 (95% CI: 0.040-0.048) SD increase in conditional height in adulthood. Short mothers (<150.1 cm) were more likely to have a child who was stunted at 2 years (prevalence ratio = 3.20 (95% CI: 2.80-3.60) and as an adult (prevalence ratio = 4.74, (95% CI: 4.13-5.44). There was no evidence of heterogeneity by site or sex. Conclusion Maternal height influences offspring linear growth over the growing period. These influences likely include genetic and non-genetic factors, including nutrition-related intergenerational influences on growth that prevent the attainment of genetic height potential in low-and middle-income countries.
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