期刊
JOURNAL OF PEDIATRICS
卷 163, 期 6, 页码 1740-U302出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2013.08.012
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资金
- Wellcome Trust [089257/Z/09/Z]
- Bill and Melinda Gates Foundation [OPP1020058]
- Pelotas Birth Cohort (Brazil): Wellcome Trust
- INCAP Nutrition Trial Cohort Study (Guatemala): US National Institutes of Health
- New Delhi Birth Cohort Study (India): Indian Council of Medical Research
- US National Center for Health Statistics
- Medical Research Council (UK)
- British Heart Foundation
- Cebu Longitudinal Health and Nutrition Study (Philippines): US National Institutes of Health
- Birth to Twenty (South Africa): Wellcome Trust
- Human Sciences Research Council
- South African Medical Research Council
- South-African Netherlands Programme on Alternative Development
- Anglo American Chairman's Fund
- University of the Witwatersrand
- Bill and Melinda Gates Foundation [OPP1020058] Funding Source: Bill and Melinda Gates Foundation
- Medical Research Council [MC_UU_12011/3, MC_UP_A620_1016] Funding Source: researchfish
- Wellcome Trust [089257/Z/09/Z] Funding Source: Wellcome Trust
- MRC [MC_UP_A620_1016, MC_UU_12011/3] Funding Source: UKRI
Objective To assess the impact of being born preterm or small for gestational age (SGA) on several adult outcomes. Study design We analyzed data for 4518 adult participants in 5 birth cohorts from Brazil, Guatemala, India, the Philippines, and South Africa. Results In the study population, 12.8% of males and 11.9% of females were born preterm, and 26.8% of males and 22.4% of females were born term but SGA. Adults born preterm were 1.11 cm shorter (95% CI, 0.57-1.65 cm), and those born term but SGA were 2.35 cm shorter (95% CI, 1.93-2.77 cm) compared with those born at term and appropriate size for gestational age. Blood pressure and blood glucose level did not differ by birth category. Compared with those born term and at appropriate size for gestational age, schooling attainment was 0.44 years lower (95% CI, 0.17-0.71 years) in those born preterm and 0.41 years lower (95% CI, 0.20-0.62 years) in those born term but SGA. Conclusion Being born preterm or term but SGA is associated with persistent deficits in adult height and schooling, but is not related to blood pressure or blood glucose level in low-and middle-income settings. Increased postnatal growth is associated with gains in height and schooling regardless of birth status, but not with increases in blood pressure or blood glucose level.
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