期刊
JOURNAL OF PEDIATRICS
卷 163, 期 5, 页码 1507-1510出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2013.06.045
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资金
- National Heart Foundation of New Zealand
- Green Lane Research and Education Fund
- Auckland Medical Research Fund
- Doris Duke Distinguished Clinical Scientist Award
- National Institutes of Health under Ruth L. Kirschstein National Research Service Award [T32 HD043010]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [P30HD062171]
- Washington University Institute of Clinical and Translational Sciences from the National Center for Advancing Translational Sciences [UL1 TR000448, KL2 TR000450]
Infants with congenital heart disease have altered brain development. We characterized cortical folding, a critical part of brain development, in congenital heart disease infants and demonstrated an overall decrease in cortical surface area and cortical folding with regional alterations in the right lateral sulcus and left orbitofrontal region, cingulate region, and central sulcus. These abnormalities were present prior to surgery.
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