期刊
JOURNAL OF PEDIATRICS
卷 160, 期 2, 页码 314-319出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2011.07.012
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资金
- National Institute of Mental Health [R01 MH063914, K23 MH01739]
- National Institutes of Health/National Institute of Mental Health, Center for Disease Control
- Tourette Syndrome Association
- Otsuka Pharmaceuticals
- Forest Pharmaceuticals
- Ortho-McNeill Janssen Pharmaceuticals
- National Institutes of Health/National Institute of Mental Health
- National Institutes of Health/National Institute of Child Health and Human Development
- Brain and Behavior Research Fund
- Foundation for Prader-Willi Research
- All Children's Hospital Research Foundation
- NARSAD
- International Obsessive-Compulsive Disorder Foundation
- University of South Florida Research Council
- Joseph Drown Foundation
Objective To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Study design Children with tics, obsessive-compulsive disorder, or both (n = 109) were examined with personal and family history, diagnostic interview, physical examination, medical record review, and measurement of baseline levels of streptococcal antibodies. Results Significant group differences were found on several variables, such that children in whom PANDAS (versus without PANDAS) were more likely to have had dramatic onset, definite remissions, remission of neuropsychiatric symptoms during antibiotic therapy, a history of tonsillectomies/adenoidectomies, evidence of group A streptococcal infection, and clumsiness. Conclusion The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of obsessive-compulsive disorder/tics. (J Pediatr 2012; 160: 314-9).
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