期刊
JOURNAL OF PEDIATRICS
卷 156, 期 1, 页码 98-U141出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2009.07.012
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资金
- Clinical Investigators of CIBERDEM (Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas, Instituto de Salud Carlos III, Madrid, Spain)
- Ministry of Education and Science, Spain
- Scientific Research (Flanders, Belgium)
Objective Puberty is part of a critical window in which adiposity and its correlates can be fine-tuned toward reproduction, which implies that puberty provides an opportunity to reprogram a misprogramming that occurred in early life. We tested this hypothesis in low-birthweight (LBW) girls with precocious pubarche (PP), who are at risk for hyperinsulinemic body adiposity during and beyond puberty. Study design LBW girls with PP (n = 38; mean age 8 years) were randomized to remain untreated or to receive metformin across puberty (425 mg/d for 2 years, then 850 mg/d for 2 years); subsequently, all girls were monitored for 1 year without intervention. Here we report on the latter year. Results The benefits of metformin were mostly maintained during the posttreatment year so that, after 5 years, metformin therapy was associated with more lean mass; with less total, visceral, and hepatic fat; with lower circulating levels of androgens and leptin; and with elevated levels of high-molecular-weight adiponectin and undercarboxylated osteocalcin. Conclusion In LBW girls with PP, pubertal metformin therapy was followed by a favorable adipokine profile and by a reduction of total, visceral, and hepatic adiposity beyond puberty. (J Pediatr 2010; 156: 98-102).
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