期刊
JOURNAL OF PEDIATRICS
卷 155, 期 2, 页码 229-234出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2009.02.030
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Objective To test the hypothesis that effects of early diet on cognition observed at age 8 years persist in adolescents born preterm at <= 30 weeks gestational age. Study design A subgroup from a preterm infant cohort recruited for a randomized trial studying the effects of early dietary intervention was assessed at age 16 years. IQ scores were compared between those assigned a high-nutrient diet (n = 49) or standard-nutrient diet (n = 46) in infancy at both 8 and 16 years. Results At age 8 years, the high-nutrient group had higher mean Verbal IQ (VIQ; P = .03), Performance IQ (P = .01), and Full-Scale IQ (P = .02) scores compared with the standard-nutrient group; the VIQ difference persisted at adolescence (P = .02). This effect was accounted for principally by a significant difference in the mean Verbal Comprehension Index score (P < .008). Conclusions A brief period of dietary intervention after preterm birth, principally between 26 and 34 weeks of gestation, affected IQ at age 16 years. A standard-nutrient diet was associated with lower VIQ; accounted for mainly by differences in verbal comprehension, which persisted after control of social factors. (J Pediatr 2009; 155:229-34).
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