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Lung Function Before and After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation: A Predictive Role for DLCOa/VA

期刊

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
卷 34, 期 4, 页码 304-309

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPH.0b013e3182346ed8

关键词

allogeneic hematopoietic stem cell transplantation; pulmonary function tests; graft-versus-host disease; DLCOa/VA; mortality

资金

  1. Riley Hospital for Children, Section of Pediatric Hematology/Oncology
  2. Pediatric Hematopoietic Stem Cell Transplantation Program

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Background: Pre-allogeneic hematopoietic stem cell transplantation (aHSCT) and post-aHSCT lung function of 41 eligible patients at Riley Hospital for Children were assessed to identify risk factors for post-aHSCT morbidity and mortality. Observations: One year post-aHSCT pulmonary function tests were significantly lower compared with baseline. These findings recovered at 2 years post-aHSCT. Refractory disease before aHSCT correlated with lower pulmonary function tests after aHSCT. Graft-versus-host disease was significantly associated with higher post-aHSCT residual volume. Importantly, low pre-aHSCT carbon monoxide diffusing capacity adjusted for hemoglobin and alveolar volume was predictive of death. Conclusions: Among survivors, lung function improves over time after pediatric aHSCT. Measurement of carbon monoxide diffusing capacity adjusted for hemoglobin and alveolar volume before pediatric aHSCT should be further investigated as a predictor of pulmonary dysfunction and mortality.

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