期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 100, 期 5, 页码 2311-2325出版社
SPRINGER
DOI: 10.1007/s00253-015-7152-6
关键词
Gallic acid; Indanone derivative; Efflux pump inhibition; Synergy; ATPase; Subacute oral toxicity
资金
- Council of Scientific and Industrial Research [MLP-02]
- CSIR Network [BSC 0121/BSC0203]
The purpose of the present study was to study the synergy potential of gallic acid-based derivatives in combination with conventional antibiotics using multidrug resistant cultures of Escherichia coli. Gallic acid-based derivatives significantly reduced the MIC of tetracycline against multidrug resistant clinical isolate of E. coli. The best representative, 3-(3', 4,' 5'-trimethoxyphenyl)-4,5,6-trimethoxyindanone-1, an indanone derivative of gallic acid, was observed to inhibit ethidium bromide efflux and ATPase which was also supported by in silico docking. This derivative extended the post-antibiotic effect and decreased the mutation prevention concentration of tetracycline. This derivative in combination with TET was able to reduce the concentration of TNF alpha up to 18-fold in Swiss albino mice. This derivative was nontoxic and well tolerated up to 300 mg/kg dose in subacute oral toxicity study in mice. This is the first report of gallic acid-based indanone derivative as drug resistance reversal agent acting through ATP-dependent efflux pump inhibition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据