期刊
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
卷 59, 期 5, 页码 565-570出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MPG.0000000000000495
关键词
Clostridium difficile infection; fecal microbiota transplantation; growth; recurrent
资金
- Gastroenterology Research Fund, Division of Gastroenterology, Department of Medicine, Sinai Hospital, Baltimore, MD (Weinberg Foundation)
- Institute for Genome Sciences (IGS), University of Maryland, Baltimore
- Gastroenterology Research Fund, Division of Gastroenterology, Department of Medicine, Sinai Hospital, Baltimore, MD (Eric Cowan Fund)
- Gastroenterology Research Fund, Division of Gastroenterology, Department of Medicine, Sinai Hospital, Baltimore, MD (Friedman & Friedman Law Firm Fund)
Fecal microbiota transplantation (FMT) is recognized as an alternative therapeutic modality for recurrent Clostridium difficile infection (RCDI); however, data on its efficacy in children are lacking, including its effect on their growth and fecal microbiota. We report on 2 young children (<3 years old) who failed available therapeutics for RCDI, but responded remarkably well to FMT. Besides resolution of clinical features of C difficile infection (CDI), FMT administration led to marked improvement in their growth, along with increased microbiota diversity, especially proportion of Bacteroides. Our 2 cases illustrate the efficacy of FMT in children with RCDI and its positive effect on their growth and gut microbiota.
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