期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 100, 期 4, 页码 1891-1900出版社
SPRINGER
DOI: 10.1007/s00253-015-7135-7
关键词
Aluminium toxicity; Aluminium binding; Antioxidative activity; Lactobacillus plantarum
资金
- National Natural Science Foundation of China Key Program [31530056]
- National Science Fund for Distinguished Young Scholars [31125021]
- National Natural Science Foundation of China [31470161, 31371721]
- BBSRC Newton Fund Joint Centre Award
- Science and Nature Foundation of Jiangsu Province [BK 20131102]
- key projects in the national science & technology pillar program during the twelfth five-year plan period [2012BAD12B02, 2012BAD28B08]
- National Basic Research Program of China (973 Program) [2012CB720802]
- 111 Project [B07019, JGB2013071]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1249]
- Biotechnology and Biological Sciences Research Council [BBS/OS/NW/000006] Funding Source: researchfish
Aluminium (Al) is the most abundant metal in the earth's crust. Al exposure can cause a variety of adverse physiological effects in humans and animals. Our aim was to demonstrate that specific probiotic bacteria can play a special physiologically functional role in protection against Al toxicity in mice. Thirty strains of lactic acid bacteria (LAB) were tested for their aluminium-binding ability, aluminium tolerance, their antioxidative capacity, and their ability to survive the exposure to artificial gastrointestinal (GI) juices. Lactobacillus plantarum CCFM639 was selected for animal experiments because of its excellent performance in vitro. Forty mice were divided into four groups: control, Al only, Al plus CCFM639, and Al plus deferiprone (DFP). CCFM639 was administered at 10(9) CFU once daily for 10 days, followed by a single oral dose of aluminium chloride hexahydrate at 5.14 mg aluminium (LD50) for each mouse. The results showed that CCFM639 treatment led to a significant reduction in the mortality rates with corresponding decrease in intestinal aluminium absorption and in accumulation of aluminium in the tissues and amelioration of hepatic histopathological damage. This probiotic treatment also resulted in alleviation of hepatic, renal, and cerebral oxidative stress. The treatment of L. plantarum CCFM639 has potential as a therapeutic dietary strategy against acute aluminium toxicity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据