期刊
JOURNAL OF PATHOLOGY
卷 225, 期 2, 页码 243-254出版社
WILEY-BLACKWELL
DOI: 10.1002/path.2934
关键词
AURKC; PLZF; cervical cancer; colorectal cancer; transformation
资金
- National Health Research Institutes [NHRI-EX99-9740NI]
- Promoting Academic Excellence and Developing World Class Research Centres [C006]
- Centre for Gene Regulation and Signal Transduction Research, National Cheng Kung University
Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear. Here we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells. Importantly, the kinase activity of AURKC is required for these tumour-associated properties. Analysis of human cancer specimens shows that the expression of AURKC is increased in cervical cancer, and is highly correlated with staging in colorectal cancer. Over-expressed AURKC-GFP localizes to the centromeric regions of mitotic chromosomes and results in a decreased level of AURKB, a key regulator of spindle checkpoint. Expression of AURKC is down-regulated by PLZF, a transcriptional repressor, through recruitment to its promoter region. The expression levels of PLZF and AURKC mRNA display opposite patterns in human cervical and colorectal cancers. Taken together, our results provide important insights into human cancers with AURKC expression, which may serve as a potential target for cancer therapy in the future. Copyright (C) 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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