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JOURNAL OF CLINICAL INVESTIGATION (2009)
Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors
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De novo LMNA mutations cause a new form of congenital muscular dystrophy
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Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation
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BIOPHYSICAL JOURNAL (2008)
Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A
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FASEB JOURNAL (2008)
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Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin
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HUMAN MOLECULAR GENETICS (2008)
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
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JOURNAL OF CELL BIOLOGY (2008)
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)
Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
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JOURNAL OF CLINICAL INVESTIGATION (2008)
Suppression of Proliferative Defects Associated with Processing-defective Lamin A Mutants by hTERT or Inactivation of p53
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Transcriptional repression mediated by repositioning of genes to the nuclear lamina
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Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
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A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
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Heart-hand syndrome of Slovenian type: a new kind of laminopathy
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New metabolic phenotypes in laminopathies:: LMNA mutations in patients with severe metabolic syndrome
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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration
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HUMAN MOLECULAR GENETICS (2007)
Cell nuclei spin in the absence of lamin B1
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
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Lamin B1 duplications cause autosomal dominant leukodystrophy
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Compound heterozygosity for mutations in LMNA causes a Progeria syndrome without prelamin A accumulation
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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Genomic instability in laminopathy-based premature aging
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Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors
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HUMAN MOLECULAR GENETICS (2005)
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Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
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JOURNAL OF CLINICAL INVESTIGATION (2004)
Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
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Lamin A truncation in Hutchinson-Gilford progeria
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Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
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Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse
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JOURNAL OF CELL BIOLOGY (2000)
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LMNA, encoding lamin A/C, is mutated in partial lipodystrophy
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
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