期刊
JOURNAL OF PATHOLOGY
卷 225, 期 1, 页码 1-3出版社
WILEY-BLACKWELL
DOI: 10.1002/path.2950
关键词
fumarate hydratase; hereditary leiomyomatosis and renal cell carcinoma; papillary renal cell carcinoma
资金
- National Institute for Health Research [NF-SI-0507-10315] Funding Source: researchfish
- Medical Research Council Funding Source: Medline
- Wellcome Trust Funding Source: Medline
In this issue of the Journal of Pathology, Bardella et al report a method for identifying tumours that lack fumarate hydratase. The approach they use is immunodetection of proteins that have been modified by a non-enzymatic reaction of thiol groups in proteins with fumarate, which is termed succination. Validation included the use of mice with targeted inactivation of fumarate hydratase in the kidney, extensive studies of normal human tissues and examination of over 1000 specimens from human cancers not associated with FH mutations. Detection of protein succination is likely to provide a sensitive and specific method for pathologists to identify the small proportion of papillary renal cell carcinomas that are associated with germline mutations in the FH gene. Copyright (C) 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据